Philippe E. Laurent






  • Philippe E. Laurent is co-founder of CreaBio Rhône-Alpes and director of consulting services.

After 12 years as head of academic research team in the field of clinical immunology and inflammatory diseases, he has more than 13 years of research and development experience within the pharmaceutical industry as director of research and development. He lead drug discovery and development team notably in the field of sleep disorder diseases achieving worldwide registration of Modiodal™ drugs currently belonging to Cephalon & Co (now TEVA). From 1997 to 2012 Philippe E. Laurent was Vice-President for Medical Affairs, and member of global executive team for BD Medical – Pharmaceutical Systems, a business segment of Becton Dickinson (BD). In 1998 he kicked off BD Saline flush project and then co-invented and run clinical development of microneedle based vaccine delivery systems –BD Soluvia™ in partnership with Sanofi Pasteur for delivery of seasonal flu vaccine. Investigations methods for assessment of nociceptive stimuli, product preference, product adoption according to condition and environment of use were developed and validated for documenting performance of injectable drug delivery systems.

Philippe E. Laurent has published numerous articles in medical and scientific peer reviewed journals and authored and/or edited several medical textbooks such as the Handbook of Clinical Immunology (Masson – 1990).

After medical school (Claude Bernard University – Lyon I – France) and his Medical Thesis (1977), he completed his medical education in basic and clinical immunology at Pasteur Institute (Paris V University – France). Philippe E. Laurent Laurent earned also a Philosophy Thesis in pharmaceutical sciencesv(1984) in the field of immuno-toxicology and immuno-pharmacology at Claude Bernard University – Lyon – France. Since 1979, and in parallel to his role as researcher for health industry,   Philippe E. Laurent is in charge of outpatient ward in clinical immunology and allergic diseases in general hospital of Givors close to Lyon.

Jean-François Nicolas

  • Jean-François Nicolas is co-founder of CreaBio Rhône-Alpes and Scientific Director of allergology and immunology studies. 

Dr. Nicolas is dermatologist and Head adjunct of the Division of Allergology and Clinical Immunology in Lyon University Hospital. He is also Professor of Immunology and Director of an INSERM research team working on “Immunology of skin allergy / Skin vaccination”. The research activities concern the skin immune system and especially the study of cellular and molecular signals that lead to immune responses or tolerance to cutaneous antigens and allergens. Applications comprise inflammatory skin diseases in humans (eczemas and drug allergy) as well as in pre-clinical mouse models of these diseases and studies of different cutaneous routes of vaccination to improve the overall efficacy of vaccines.

Dr. Nicolas received his M.D. degree from Lyon University Medical School in 1983. His dermatology specialty degree was obtained through specific training in immunodermatology (Pr Jean Thivolet). He obtained his PhD degree in 1990 after a pos-doctoral fellowship at Scripps Clinic and University of California San-Diego (Dr Jacques Chiller) and after being a recipient of INSERM young investigator award. He occupied the position of research director at INSERM from 1990 to 1998.

Dr. Nicolas has authored and/or co-authored more than 150 research papers and book chapters. In addition, he is the co-editor of the European Journal of Dermatology.

Catherine Goujon

  • Catherine Goujon is co-founder of CreaBio Rhône-Alpes and Scientific Director of dermatology and cosmetology studies.

Dr. Goujon is a dermatologist and received his M.D. degree from Lyon University Medical School in 1980. His dermatology specialty degree was obtained in 1981.
She is responsible for the Clinical Research Unit in Immunology in Lyon South Hospital (URCI-LS).

Since its creation in 2001, URCI-LS has carried out, in accordance with Good Clinical Practice, the French Law and the Helsinki declaration, more than hundred clinical trials in the following areas:

  • Pathology : psoriasis, atopic dermatitis, eczema, allergy to perfumes and nickel, urticaria
  • Skin physiology : investigations on skin thickness thanks to ultrasounds at different anatomical sites, assessment of skin ageing
  • Vaccinology : evaluation of new vaccination techniques
  • Skin tolerance to drugs: evaluation of skin reactions induced by non steroidal anti-inflammatories, psychotropes, anticoagulants…

To date, more than 5000 patients or healthy volunteers have been included in a study or a clinical trial.

Frédéric Mistretta







  • Frédéric Mistretta is co-founder of CreaBio Rhône-Alpes and director of clinical research. 

F. Mistretta is a biostatistician and has been Head of the RCTs’ biostatistic department since 1998. He obtained a Master of Science degree in 1995 at the University of Poitiers, including a multidisciplinary teaching in physiology, biochemistry, computing and statistics. He has also been a managing Partner of RCTs since 2004.

F. Mistretta is a senior consultant in methodology and biostatistics in clinical trials as well as in PharmacoEpidemiology studies for the Pharmaceutical and Medical Devices industries. He is a fellow of the French CRO Federation PharmacoEpidemiology Working Group and is teaching biostatistics in the University of Poitiers.

F.Mistretta has managed hundreds of statistical analyses and has co-authored more than 20 clinical or methodological research papers.

Yves Alamercery





  • Yves Alamercery is co-founder of CreaBio Rhône-Alpes and Financial & Administrative Director. 

Prior to founding Randomized Clinical Trials (RCTs) in 1989, Yves Alamercery was the Head of Computers Department of the Clinical Pharmacology Unit directed by Prof. J.P. Boissel in Lyon (France). RCTs is a Contract Research Organization located in Lyon, >400 clinical trials, phase I to phase IV services, in a wide range of therapeutic areas, over 100 000 patients, over 50 million variables treated. RCTs is the French office of PSN, a full-service global Contract Research Organization with over 200 employees in 11 countries across Northern America and Europe.

Yves Alamercery has a strong experience in phase II to IV clinical trials in cardiology, rheumatology, oncology, endocrinology, infectious diseases, CNS… He is an active member of the AFCRO (French association of CROs). Yves graduated from the University of Poitiers with a degree in physiology and computer sciences.

Marc Fantino

  •  Marc Fantino is co-founder of CreaBio Rhône-Alpes and Scientific Director for nutrition & food studies. 

Pr Marc Fantino, physician and PhD, headed for more than 30 years the Department of Human Physiology and Functional Explorations of Dijon University Hospital. During this period, he led basic and applied research on metabolic, neurophysiological and sensory determinism of food behavior and energetic regulation in human and animal.

Director of the Doctoral School of Life Sciences and Health at the University of Bourgogne (ED 174) from 1993 to 2001, he was one of the founders of the European Centre for Science of Taste and Food Behaviors situated in Dijon.
Expert with several companies and national and international public authorities, he was a member of the committee of experts specialized in Human Nutrition of the AFSSA (French agency for security and hygiene of foods) from 1999 to 2008. He also chaired the award committee of the Health and Nutrition National Program logo from 2004 to 2012.

Currently he leads an applied research activity thanks to the Resource Centre for Applied Biomedical Research (CREABio ®) he created in 1990, whose purpose is to study, in conjunction with the industrial world of human foods, the relationship between diet and health, and to demonstrate the accuracy of health claims. In 2013, CREABio-Dijon becomes CreaBio Rhône-Alpes.